WELCOME TO ASAHI KASEI MEDICAL AMERICA INC.

We are dedicated to the advancement of world-leading technology in the fields of hemodialysis, therapeutic apheresis, transfusion therapy, and virus removal for biotherapeutic products. At Asahi Kasei Medical America Inc., we constantly work to introduce innovative therapies for intractable diseases by extending the frontiers of medical devices and systems, combining our core technology in functional materials for membrane filtration and selective adsorption with advance pharmacology, chemistry, and mechanical engineering.

Dialysis Bloodlines

Asahi's bloodlines are medical grade tubing with a variety of models available for most brands of hemodialysis machines. Designed for convenience and safety they are latex free and are available ETO and gamma-sterilized. With color coded injection port makes for easy operation.

Cascadeflo™

Asahi's Cascadeflo™ is a plasma component separator used in conjunction with the plasma separator Plasmaflo™ in double filtration plasmapheresis (DFPP) systems to remove high molecular-weight substances from separated plasma. DFFP in combination with Plasmaflo™ OP and Cascadeflo™ EC-50W requires no substitution fluid, and therefore there is no risk of infection from a substitution fluid. Available in four different pore sizes.

Cellsorba™

Cellsorba™ FX is a leukocytapheresis column used in the treatment of inflammatory bowel disease. Cellsorba™ FX selectively removes leukocytes (e.g., lymphocytes, granulocytes, monocytes) implicated in the inflammatory process.

Cureflo™

Asahi's hemofilter, the CUREFLO™ is a polysulphone hollow fiber filter for continuous renal replacement therapy (CRRT) intended for the treatment of patients with renal failure with concomitant severe cardiovascular complications such as cardiac insufficiency and edema, which cannot be sufficiently resolved with intermittent hemodialysis or hemofiltration. The filters used for CRRT can be selected from various materials and surface area models depending on disease type and patient status.

EVAL™

Asahi's EVAL™ EVOH is unique because of its single synthetic polymer membrane having both hydrophilic and hydrophobic segments. With a lower degree of platelet reactivity than other membranes EVAL™ EVOH provides great biocompatibility.

Immusorba™

Immusorba™ separators are used in immunoadsorption (IA) systems in conjunction with the plasma separator Plasmaflo to remove antibodies and other pathogenic substances from separated plasma. Therefore, no replacement gluid is required. Average Bead Size is 100 micrometer and pore size of 0.05 micrometer and an adsorbent volume of 350 ml. Immusorba™ TR is an immunoadsorption (IA) column with tryptophan immobilized in polyvinylacohol gel. It is used for the treatment of immune neurological diseases such as Myasthenia Gravis and Guillain-Barré syndrome. The column is specifically designed to remove and adsorb antibodies including anti-acetylcholine receptor antibody or immunocomplexes from separated plasma via the hydrophobic and ionic interaction with tryptophan. Immusorba™ PH is an immunoadsorption (IA) column with phenylalanine immobilized in polyvinylacohol gel. It is used for the treatment of autoimmune diseases such as Multiple Sclerosis, Guillain-Barré syndrome, Rheumatoid Arthritis and Systemic Lupus Erythematosus. The column is specifically designed specifically to remove and adsorb antibodies including anti-DNA receptor antibody or immunocomplexes from separated plasma via the hydrophobic and ionic interaction with phenylalanine.

Dialysis Machine MDS-101

Asahi's MDS-101 features the latest in dialysis machine technology. With its slim design to enable more treatments within clinics and 12 inch wide color LCD touch panel featuring keys lined in order of procedural steps this machine provides one of the most simplified operations on the market. Other features include: Improved safety and reliability

• Closed circuit chamber system with improved ultra filtration pump
• Constant pressure system independent of dialysis fluid pressure enhances the filtration accuracy

Ample extensive functions
• UF profile and sodium profile are provided
• Equipped with back-up battery for emergency power supply
• Equipped with air detectors for arterial line and substitution line
• Optional blood pressure manometer is available
• Online bicarbonate preparation

Enhanced maintainability
• Latest incidence details are recorded and displayed on the History Screen for use in incidence analysis and maintenance.

OUR MISSION STATEMENT

Asahi Kasei Medical America is driven to merge the best possible patient outcomes with a highly supportive and streamlined customer experience by utilizing our technology and expertise. As we move forward, we are committed to improving the care of our patients through our dedication to research and development. We do this with an understanding of the global environment and with a commitment to the medical industry we serve.

Dialysis Needles

Ultra thin wall combined with a uniquely thin blade reduces pain and damage to the vessel for smoother penetration. Color-coded wings make for easy recognition of gauge sizes. Asahi offers a wide range of product lineup including short and long tube lengths with a variety of needle lengths.

Plasmaflo™

Asahi's Plasmaflo™ OP is a plasma separator for plasmapheresis. Plasmaflo™ OP separates plasma from the whole blood and is used in therapeutic plasma exchange (TPE) and as the first filter in double filtration plasmapheresis (DFPP), plasma adsorption (PA), and immunoadsorption (IA). It contains a hydrophilized polyethylene hollow-fiber membrane with a unique pore structure. Selectively removes hepatic toxins, amino acids, coma-producing substances such as ammonia, and various autoantibodies. Plasmaflo-OP™ is available with surface areas of 0.2m , 0.5m , and 0.8m .

Plasorba™

The Plasorba™ plasma perfusion column is used in conjunction with a plasma separator for the selective adsorption and removal of bilirubin and bile acid from separated plasma. Plasorba™ uses anion-exchange resin for absorption and thus requires no supplementary plasma. In addition, the low priming volume reduces the physical burden on patients during treatment. Indications for Plasorba™ use are liver disease such as fulminant hepatitis, postoperative hepatic failure, and hyperbilirubinemia.

OUR PRESIDENT

Mike Jackson Mike is the President of Asahi Kasei Medical America Inc. and is a member of its Board of Directors. Mike's career has spanned over 25 years in all facets of the dialysis industry including research and development, sales management, marketing and administration. Mike has focused Asahi Kasei Medical America Inc. to become a key player in the global strategy for Asahi Kasei Medical based out of Tokyo, Japan. Since joining Asahi Kasei Medical in 2002, Mike gained valuable experience at his position at Terumo Medical of Somerset, New Jersey. Mike received his Bachelor of Science in Biology from Eastern Michigan University.

REXEED-A

Asahi's REXEED-A has proven to be one of the highest performing single use dialyzers in the market. Packed in reverse osmosis water, it provides exceptional urea, creatinine, and phosphate clearances while minimizing the need for heparin.

REXEED-AX

Asahi's REXEED-AX is a high flux dialyzer that demonstrates the same high levels of performance as all dialyzers in the REXEED product family, but is dry sterilized by E-beam. This dialyzer features a light weight design for ease of handling and produces less waste through its dry design.

REXEED-L

REXEED-L demonstrates quality performance in a low flux design. REXEED-L is packed in sterile water and exhibits the same characteristics of all Rexeed dialyzer utilizing the Rexbrane membrane.

REXEED-LX

Asahi's first low flux dry dialyzer, REXEED-LX demonstrates quality performance in a low flux design and is dry sterilized by E-beam. This dialyzer features a light weight design for ease of handling and produces less waste through its dry design.

REXEED-R

REXEED-R is manufactured for the United States reuse market. Packed in reverse osmosis water, this dialyzer has exceptional reuse capabilities. This dialyzer maintains the clearance values through out its reuse life.

REXEED-S

Asahi's REXEED-S has proven to be one of the highest performing single use dialyzers in the market. Packed in reverse osmosis water, it provides exceptional urea, creatinine, and phosphate clearances while minimizing the need for heparin.

REXEED-SX

Asahi's REXEED-SX is a high flux dialyzer that demonstrates the same high levels of performance as all dialyzers in the REXEED product family, but is dry sterilized by E-beam. This dialyzer features a light weight design for ease of handling and produces less waste through its dry design.

Rheofilter

Rheofilter™ is a plasma component separator specifically designed for Rheopheresis™ to treat microcirculatory disorders or impaired microcirculation. The Rheofilter™ is used as part of an extracorporeal double filtration (membrane differential filtration) system in combination with a plasma separator (Plasmaflo™) for selective extracorporeal plasma therapy, e.g. Rheopheresis™. Rheopheresis™ falls under the category of double filtration plasmapheresis (DFPP). Rheofilter™ removes fibrinogen and larger molecular weight substances in the treatment of conditions involving microcirculatory disorders (e.g., age-related macular degeneration).

Plasmapheresis Machine Plasauto Sigma

Plasauto ™ is a multifunctional system for therapeutic apheresis and Continuous Renal Replacement Therapy (CRRT) ideal for clinical sites. It realizes the three S: speedy, safety, and smart. With new developed cassette tubing and a multi-CPU system, the machine is fully equipped with advanced high specifications. Designed to meet future generation needs, Plasauto ™ leads the blood purification field with excellent reliability. Features include: * Therapeutic Apheresis Applications: PE, DFPP, PA, LCAP, HA * CRRT Applications: CVVH, CVVHD, CVVHDF, SCUF * Easy setup, one-step panel tubing, no concern with mistakes, since the use of the cassette tubing ensures correct positioning of the air detectors, designed to take 5 minutes to load * LED touch screen provides visual guidance for tubing setup, as well as the location of the error and actions to take in response to alarms and troubleshooting * Inlet and outlet of the 2nd filter or column to be warmed in TPE and CRRT mode. * Unique fluid removal control technology * Resistant to external shock, measurement unit is protected against vibrations and contact, thus minimizing interruption of treatment

ViE™

VitabranE™ polysulfone dialyzers have been introduced to deal with the problem of reactive oxygen species by coating the blood side of the membrane with the antioxidant vitamin E. It has been shown that the level of antioxidant activity or vitamin E's ability to scavenge active oxygen within the membrane is very high, with the antioxidant response being site specific at the point of highest free radical formation. VitabranE™ has also been shown to improve the life of red blood cells therefore optimizing EPO usage.